| Autor: |
A, Härtl, U, Möllmann, E, Schrinner, A, Stelzner |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
Arzneimittel-Forschung. 47(9) |
| ISSN: |
0004-4172 |
| Popis: |
Embryonated hens' eggs can be reliably infected by Pseudomonas aeruginosa in laboratory experiments. Therapy tests with the antibiotics azlocillin (CAS 37091-66-0) and gentamicin (CAS 13291-74-2) on this type of infected hens' eggs demonstrate that this test system offers a realistic alternative to septic experiments with small laboratory rodents. Chick embryos survive a lethal Pseudomonas infection when azlocillin or gentamicin in a relevant therapeutic dose are administered immediately after the infective agent. The use of Pseudomonas infected chick embryos in the screening for new antiinfectives allows, therefore, a considerable reduction of the number of laboratory rodents required. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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