Cadmium and/or selenium effects on guinea pig lung PGE2, TXB2 and LTC4

Autor:	R R, Bell, M R, Soliman, V K, Nonavinakere, D M, Hammerbeck, J L, Early
Rok vydání:	1997
Předmět:	Male Thromboxane B2 Sodium Selenite Cadmium Chloride Guinea Pigs Carcinogens Animals Drug Synergism Lung Dinoprostone Leukotriene C4
Zdroj:	Research communications in molecular pathology and pharmacology. 97(2)
ISSN:	1078-0297
Popis:	Male Hartley guinea pigs (480-610 g; n=5) were treated intratracheally with saline, cadmium (Cd, 0.3 mg) as cadmium chloride, selenium (Se, 0.3 or 0.06 mg) as sodium selenite or Se (0.06 mg) and Cd (0.3 mg). After 24 hours, lungs were collected and analyzed for prostaglandin (PGE2), thromboxane (TXB2) and leukotriene (LTC4) levels. Results indicated that, 0.3 mg Se and 0.06 mg Se in combination with 0.3 mg Cd increased PGE2 significantly. Selenium and Cd alone or in combination, decreased LTC4 and TXB2 significantly.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a8aa6ea9a50b61b059d937401a3e091a https://pubmed.ncbi.nlm.nih.gov/9344235 Zobrazit plný text záznamu