| Autor: |
Achyut Ram, Vyakaranam, Joakim, Crona, Olov, Norlén, Dan, Granberg, Ulrike, Garske-Román, Mattias, Sandström, Katarzyna, Fröss-Baron, Espen, Thiis-Evensen, Per, Hellman, Anders, Sundin |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Cancers |
| ISSN: |
2072-6694 |
| Popis: |
Peptide receptor radiotherapy (PRRT) with 177Lu-DOTATATE has emerged as a promising therapy for neuroendocrine tumors (NETs). This retrospective cohort study aimed to assess the outcome of PRRT for 22 patients with histopathologically confirmed pheochromocytoma (PCC) and paraganglioma (PGL), of which two were localized and 20 metastatic. Radiological response utilized response evaluation criteria in solid tumors 1.1 and toxicity was graded according to common terminology criteria for adverse events version 4. Median 4 (range 3–11) 7.4 GBq cycles of 177Lu-DOTATATE were administered as first-line therapy (n = 13) or because of progressive disease (n = 9). Partial response (PR) was achieved in two and stable disease (SD) in 20 patients. The median overall survival (OS) was 49.6 (range 8.2–139) months and median progression-free survival (PFS) was 21.6 (range 6.7–138) months. Scintigraphic response >50% was achieved in 9/19 (47%) patients. Biochemical response (>50% decrease) of chromogranin A was found in 6/15 (40%) patients and of catecholamines in 3/12 (25%) patients. Subgroup analysis showed Ki-67 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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