| Autor: |
Kae Chang, Park, Shinichi, Toyonaga, Hiromichi, Nakabayashi, Hikaru, Mizobuchi, Eiichi, Nakai, Naoki, Ikawa, Keiji, Shimizu |
| Rok vydání: |
2004 |
| Předmět: |
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| Zdroj: |
Anticancer research. 24(2C) |
| ISSN: |
0250-7005 |
| Popis: |
This case report describes an 11-year-old boy with primitive neuroectodermal tumor (PNET), which remains the pediatric brain tumor with the worst prognosis despite combination treatment with surgery, irradiation and anti-cancer drugs. The boy was successfully treated with intratumoral administration of interferon-beta (IFN-beta) following surgical resection and irradiation. Two million units of IFN-beta were locally administered into the post-operative cavity through the Ommaya's reservoir every two weeks after discharge. He was managed as an outpatient without serious side-effects to IFN. The patient has shown no tumor recurrence, mental retardation, or neuroendocrine impairment for over three years and has lived a normal school life with a full Karnofsky Performance Status score. The local administration of IFN-beta may be warranted for maintenance therapy in children with PNET. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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