| Autor: |
M N, Rossor, N C, Fox, P A, Freeborough, P K, Roques |
| Rok vydání: |
1997 |
| Předmět: |
|
| Zdroj: |
Alzheimer disease and associated disorders. 11 |
| ISSN: |
0893-0341 |
| Popis: |
The search for biologic markers of Alzheimer disease (AD) progression has thus far had limited success. A technique is described, involving magnetic resonance imaging, that can be used to follow the progress of brain atrophy and hence the loss of neuronal tissue. It involves acquisition of three-dimensional images of the brain on two consecutive occasions and their precise co-registration so as to assess the loss of tissue volume over time. Median loss of brain volume in a group of individuals with sporadic and familial AD ranged from about 5-20 ml/year compared to less than 2 ml/year for controls. Loss of cerebral tissue volume was also seen in two individuals from a pedigree with familial AD at a time when symptoms were only just apparent. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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