Investigator-reported efficacy of azelaic acid foam 15% in patients with papulopustular rosacea: secondary efficacy outcomes from a randomized, controlled, double-blind, phase 3 trial

Autor:	James A, Solomon, Stephen, Tyring, Gerald, Staedtler, Meike, Sand, Richard, Nkulikiyinka, Kaweh, Shakery
Rok vydání:	2016
Předmět:	Dosage Forms Male Treatment Outcome Double-Blind Method Rosacea Humans Dicarboxylic Acids Female Dermatologic Agents Symptom Assessment Administration Cutaneous Severity of Illness Index
Zdroj:	Cutis. 98(3)
ISSN:	2326-6929
Popis:	Papulopustular rosacea (PPR) is characterized by centrofacial papules and pustules commonly associated with erythema. To compare investigator-reported efficacy outcomes for azelaic acid (AzA) foam 15% versus vehicle foam in PPR, a randomized, vehicle-controlled, double-blind phase 3 clinical trial was conducted at 48 US sites. Participants received AzA foam or vehicle foam for 12 weeks. Secondary efficacy outcomes included change in inflammatory lesion count (ILC), therapeutic response rate according to investigator global assessment (IGA), and change in erythema rating. This study was comprised of 961 participants with PPR. The results support the therapeutic superiority of AzA foam over vehicle foam.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a7cd4a1f641fdf7609b095119ca0b715 https://pubmed.ncbi.nlm.nih.gov/27814413 Zobrazit plný text záznamu