| Autor: |
Fiona, Wu, Toni, Staykova, Anne, Horne, Judy, Clearwater, Ruth, Ames, Barbara, Mason, Brandon, Orr-Walker, Gregory, Gamble, Marilyn, Scott, Ian, Reid |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
The New Zealand medical journal. 116(1179) |
| ISSN: |
1175-8716 |
| Popis: |
Treatment of vitamin D deficiency is an important aspect of the management of osteoporosis, particularly in the elderly. Most well-described regimens in current use involve daily dosing and thus require long-term compliance to be effective. In New Zealand, no preparation containing only low-dose vitamin D suitable for daily use is available. We describe a high-dose regimen for rapid correction of vitamin D deficiency, which makes use of the calciferol 50 000 international unit (IU) tablets available in this country.Thirty two women (mean age 76 +/- 4 years; range 67-84 years) with serum 25-hydroxyvitamin D concentrations = or10 microg/l were treated with oral calciferol 50 000 IU daily for 10 days.At an average time after treatment of four months, serum 25-hydroxyvitamin D increased from 8 +/- 1 microg/l to 21 +/- 5 microg/l, bringing all but one patient within the reference range (14-76 microg/l). Serum parathyroid hormone level decreased after treatment by 0.7 +/- 1.7 pmol/l (p0.05), and alkaline phosphatase activity decreased by 5 +/- 11 u/l (p0.05). Serum calcium increased by 0.06 +/- 0.08 mmol/l (p0.001), but all values were within the reference range. Data collected from a separate cohort of elderly inpatients showed that similar increases could be achieved with a single 300 000 IU dose, and suggested that serum 25-hydroxyvitamin D levels decline with a half-life of 90 days.This regimen provides a simple, safe and effective way of managing vitamin D deficiency. Its short-term nature may result in higher compliance than daily dosing regimens. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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