| Autor: |
Lars J, Petersen, Michael, Gade, Randi F, Fonager, Signe, Albertsen, Joan, Fledelius, June A, Ejlersen, Mette H, Christensen, Ramune, Aleksyniene, Helle D, Zacho |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Hellenic journal of nuclear medicine. 24(1) |
| ISSN: |
1790-5427 |
| Popis: |
The correlation between the computer-assisted bone scan index (BSI) responses versus clinical response classification if bone metastases in prostate cancer patients are not clear. We compared changes in BSI with Prostate Cancer Working Group-3 (PCWG3) and MD Anderson (MDA) criteria.Fifty-six consecutive patients with at least two bone scans (BS) within 12 months were included, who had BS before and after treatment with the same anticancer agent.Progressive disease (PD) by PCWG3 criteria was seen in 28% of the cases (median BSI increased by 1.69 units) versus non-PD in 72% (BSI change -0.13). MDAnderson showed PD in 34% (BSI increase 0.49), 45% stable disease (BSI change 0.00), and 20% partial responses (BSI decrease 1.44). Absolute BSI changes differed significantly among response categories by PCWG3 and MDA criteria (both P0.0001). Response classification using dichotomized BSI data (0/≤0 and0.3/≤0.3 BSI units) showed a significant correlation with PCWG3 and MDA criteria (all P0.001). Absolute BSI changes and dichotomized BSI correlated to prostate-specific antigen responses (both P0.001) but not to clinical responses.Absolute changes in BSI and BSI response classification correlated significantly with standardized clinical response criteria for the assessment of treatment responses of skeletal metastases in prostate cancer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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