Therapeutic Options in Pregnant Women with Thrombophilia Depending on the Genetic Mutations- a Prospective Study

Autor:	NACEA, J.G., ROTARU, I., PATRASCU, A.M., CERNEA, N.
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Original Paper pregnancy outcome Aspirin Clexane Thrombophilia
Zdroj:	Current Health Sciences Journal
ISSN:	2069-4032 2067-0656
Popis:	The aim is to evaluate the effects of anticoagulant therapy (Enoxaparine) compared to antiaggregant therapy (Aspirin) on pregnancy outcome depending on the mutational status of clotting factors. The study was conducted prospectively over a 2 years period and included 110 pregnant women, of whom 80 patients diagnosed with hereditary thrombophilia and 30 healthy pregnant women, representing the control group. After careful observation, we concluded a positive influence of Enoxaparine on pregnancy outcome in pregnant women homozygous carriers for factor V Leiden gene mutation and compound heterozygous for Factor V Leiden and Prothrombin G20210A gene mutation. The study did not find significant positive results in women with heterozygous Factor V Leiden and G20210A prothrombin gene mutation who received anticoagulant therapy as well as pregnant women who received low-dose Aspirin compared with controls.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a78a338d7211f9b8c98a4794a06384f6 http://europepmc.org/articles/PMC6311225 Zobrazit plný text záznamu Plný text ve formátu PDF