Effects of pore size, implantation time, and nano-surface properties on rat skin ingrowth into percutaneous porous titanium implants

Autor:	Brad J, Farrell, Boris I, Prilutsky, Jana M, Ritter, Sean, Kelley, Ketul, Popat, Mark, Pitkin
Rok vydání:	2013
Předmět:	Titanium Time Factors Staining and Labeling Surface Properties technology industry and agriculture equipment and supplies Article Rats Prosthesis Implantation Rats Sprague-Dawley Implants Experimental Linear Models Animals Nanoparticles Porosity Hair Skin
Zdroj:	Journal of biomedical materials research. Part A. 102(5)
ISSN:	1552-4965
Popis:	The main problem of percutaneous osseointegrated implants is poor skin-implant integration, which may cause infection. This study investigated the effects of pore size (Small, 40–100 microns and Large, 100–160 microns), nanotubular surface treatment (Nano), and duration of implantation (3 and 6 weeks) on skin ingrowth into porous titanium. Each implant type was percutaneously inserted in the back of 35 rats randomly assigned to 7 groups. Implant extrusion rate was measured weekly and skin ingrowth into implants was determined histologically after harvesting implants. It was found that all 3 types of implants demonstrated skin tissue ingrowth of over 30% (at week 3) and 50% (at weeks 4–6) of total implant porous area under the skin; longer implantation resulted in greater skin ingrowth (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a77c3e01223c8698014092db7be90cd5 https://pubmed.ncbi.nlm.nih.gov/23703928 Zobrazit plný text záznamu Plný text