Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons

Autor:	M, Migliore, D A, Hoffman, J C, Magee, D, Johnston
Rok vydání:	1999
Předmět:	Potassium Channels Pyramidal Cells Models Neurological Synapses Electric Conductivity Potassium Reaction Time Action Potentials Computer Simulation Dendrites Hippocampus
Zdroj:	Journal of computational neuroscience. 7(1)
ISSN:	0929-5313
Popis:	Action potentials elicited in the axon actively back-propagate into the dendritic tree. During this process their amplitudes can be modulated by internal and external factors. We used a compartmental model of a hippocampal CA1 pyramidal neuron to illustrate how this modulation could depend on (1) the properties of an A-type K+ conductance that is expressed at high density in hippocampal dendrites and (2) the relative timing of synaptic activation. The simulations suggest that the time relationship between pre- and postsynaptic activity could help regulate the amplitude of back-propagating action potentials, especially in the distal portion of the dendritic tree.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a76294d054f00e54cb38118c20b1c899 https://pubmed.ncbi.nlm.nih.gov/10481998 Zobrazit plný text záznamu Full text from SpringerLink