Interactions between outcomes and tumor response to preoperative cisplatin-sensitized radiotherapy in advanced head and neck cancer. Southern New Jersey Head and Neck Cancer Treatment Group

Autor:	M D, Goodman, M, Tarnoff, M, Kain, G J, Slotman
Rok vydání:	1997
Předmět:	Male Radiation-Sensitizing Agents Time Factors Antineoplastic Agents Middle Aged Combined Modality Therapy Survival Rate Treatment Outcome Head and Neck Neoplasms Carcinoma Squamous Cell Humans Female Cisplatin Follow-Up Studies Retrospective Studies
Zdroj:	American journal of surgery. 174(5)
ISSN:	0002-9610
Popis:	Whether or not tumor response to chemotherapy-sensitized radiation therapy (CTRT) for head and neck cancer leads to an improved outcome is unknown.Forty patients who received preoperative cisplatin plus simultaneous radiotherapy for operable stage III and IV head and neck cancer were reviewed retrospectively regarding clinical demographics, staging, and survival status.Twenty-one (57%) patients had a histologic complete response (HCR) and 16 (43%) had a partial (PR) (9) or clinical complete (7) response (CCR). Tumor response of N1 versus N2-3 nodal disease showed 6 (75%) HCR and 4 (25%). Five-year disease-free survival overall was 82% for HCR versus 38% for PR/CCR (P0.05). Disease-specific 5-year survival was 100% for HCR versus 27% for PR/CCR (P0.002).Histologic complete response to CTRT for head and neck cancer is associated with increased survival and encouraging disease-free status. Response to CTRT is inversely proportional to lymphatic tumor load.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a74965a1ef92666e371634405da9b960 https://pubmed.ncbi.nlm.nih.gov/9374230 Zobrazit plný text záznamu Full Text from ScienceDirect