| Autor: |
D A, Vilenskiĭ, N G, Levitskaia, L A, Andreeva, L Iu, Alfeeva, A A, Kamenskiĭ, N F, Miasoedov |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 93(6) |
| ISSN: |
0869-8139 |
| Popis: |
Effects of chronic intranasal administration of ACTH(4-10) analog Semax (MEHFPGP) on exploratory activity, anxiety level, and depression-like behaviour were studied in white rats. The peptide was injected daily in dose 0.05 mg/kg during 10 or 14 days. It was shown that chronic Semax administration at 1-2 weeks induced anxiolytic and antidepressant effects but did not influenced the exploratory activity in non-stressogenic environment. The Semax effects may be the results of activation of the brain serotoninergic system as well as increased BDNF expression in the rat hippocampus. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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