Acquisition of contextual Pavlovian fear conditioning is blocked by application of an NMDA receptor antagonist D,L-2-amino-5-phosphonovaleric acid to the basolateral amygdala

Autor:	M S, Fanselow, J J, Kim
Rok vydání:	1994
Předmět:	Electroshock 2-Amino-5-phosphonovalerate Conditioning Classical Exploratory Behavior Animals Association Learning Female Fear Motor Activity Amygdala Social Environment Receptors N-Methyl-D-Aspartate Rats
Zdroj:	Behavioral neuroscience. 108(1)
ISSN:	0735-7044
Popis:	Rats, with chronic cannula placed bilaterally in the amygdala, received infusions of the N-methyl-D-aspartate (NMDA) receptor antagonist D,L-2-amino-5-phosphonovaleric acid (APV) before contextual Pavlovian fear conditioning. Administration of APV to the basolateral nucleus prevented acquisition of fear. Central nucleus infusions had no effect. It is concluded that an NMDA-mediated process near the basolateral region of the amygdala (e.g., lateral or basolateral nucleus) is essential for the learning of fear.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a6d7ceccd6788e3c6e2721f8c2559036 https://pubmed.ncbi.nlm.nih.gov/7910746 Zobrazit plný text záznamu