| Autor: |
S A, Hatanaka, N O, Silva, B S, Colombo, C G, Correa, B P, Alcaire, M H, Coral, L L, Schiavon, J L, Narciso-Schiavon |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Minerva gastroenterologica e dietologica. 61(3) |
| ISSN: |
1827-1642 |
| Popis: |
Metabolic syndrome and type 2 diabetes are associated with insulin resistance and hepatic steatosis, which are common causes of alanine aminotransferase (ALT) elevation. This study aims to identify variables associated with altered ALT in type 1 diabetic (DM1) subjects.A cross-sectional study conducted in the outpatient endocrinology clinic of a university hospital. Patients with DM1 were seen between December 2012 and September 2013; clinical variables were collected from medical records.Fifty-six patients were included aged 27 ± 10.1 years; 60.7% were men. The study subjects exhibited an average ALT of 36.7 ± 10.3 U/L (median = 35 U/L) and their average Body Mass Index (BMI) was 23.8 ± 3.8 kg/m2. When comparing individuals with elevated ALT35 U/L (N. = 27) with those ALT ≤ 35 U/L (N. = 29), we found that individuals with ALT values35 U/L showed a higher proportion of men (77.8% vs. 44.8%, P = 0.012) and a higher mean age (30.2 ± 12.3 vs. 24.6 ± 6.9 years, P = 0.046). When new ALT reference values were applied (19 U/L for women and 30 U/L for men), five individuals had normal ALT values. Individuals with elevated ALT had higher BMI (24.3 vs. 20.9; P = 0.036), fasting glucose (194.8 ± 101.2 vs. 123.6 ± 42.0 mg/dL; P = 0.013) and higher HbA1c (9.9 ± 2.8 vs. 7.8 ± 0.7%; P0.001) levels. In Pearson correlation analysis, ALT values correlated with HbA1c (r = 0.285; P = 0.033).In patients with DM1, elevated ALT values are associated with BMI, fasting glucose and HbA1c. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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