| Autor: |
F, Claudiani, A, Garaventa, L, Bertolazzi, G P, Villavecchia, M, Cabria, G, Scopinaro, M, Bestagno, P, Guerra, N, Canevarollo, G, Scielzo |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Journal of nuclear biology and medicine (Turin, Italy : 1991). 35(4) |
| ISSN: |
0368-3249 |
| Popis: |
Forty-two children with advanced neuroblastoma who either failed with first-line therapy or relapsed after achieving a complete remission, were considered for treatment with [131I]metaiodobenzylguanidine (131I-MIBG). We subdivided 42 cases into 5 groups, in accordance with the stage of disease at diagnosis, response to first-line therapy and relapse. A total of 99 courses of 131I-MIBG were administered with doses ranging from 2.8 to 6.0 GBq. One child received six courses, 3 four courses, 18 three courses, 6 two courses and 15 one course of 131I-MIBG. The total delivered dose in single measurable lesions ranged from 286 to 1691 cGy with an uptake factor ranging from 3% to 10%. We obtained a major response in primary tumors, and a long-term response was observed in 5 cases, lasting more than 2 years without further chemotherapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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