| Autor: |
D H, Staniforth, D, Jackson, R, Horton, B, Davies |
| Rok vydání: |
1984 |
| Předmět: |
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| Zdroj: |
International journal of clinical pharmacology, therapy, and toxicology. 22(8) |
| ISSN: |
0174-4879 |
| Popis: |
The pharmacokinetics of intravenous Augmentin have been investigated and the data found to fit a two compartment model. In the first study, to a crossover design, a bolus injection of 1.2 g Augmentin was given to 8 healthy volunteers with and without probenecid. It was found that the serum concentrations of amoxycillin were increased in the presence of probenecid, but those of clavulanic acid were unaffected. In a second study a further 8 volunteers received an infusion over 30 min of 2.2 g Augmentin. At the end of the infusion, peak concentrations in excess of 100 micrograms/ml were recorded for amoxycillin and 14 micrograms/ml for clavulanic acid. In both studies the serum and urinary concentrations of amoxycillin and clavulanic acid obtained were well above those considered necessary to achieve a therapeutic effect. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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