Serum tenascin-C as a potential predictive marker of angiogenesis in non-small cell lung cancer
| Autor: | Toshiji, Ishiwata, Kazuhisa, Takahashi, Yuri, Shimanuki, Rina, Ohashi, Ri, Cui, Fumiyuki, Takahashi, Kazue, Shimizu, Kayo, Miura, Yoshinosuke, Fukuchi |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A Lung Neoplasms Time Factors Sialoglycoproteins Oligosaccharides Adenocarcinoma Cell Movement Carcinoma Non-Small-Cell Lung Biomarkers Tumor Humans Sialyl Lewis X Antigen Cells Cultured Aged Cell Proliferation Dose-Response Relationship Drug Neovascularization Pathologic Microcirculation Tenascin Middle Aged Prognosis Immunohistochemistry Recombinant Proteins Carcinoembryonic Antigen Female Osteopontin Endothelium Vascular |
| Zdroj: | Anticancer research. 25(1B) |
| ISSN: | 0250-7005 |
| Popis: | Tenascin (Tn)-C is an extracellular matrix protein that is involved in tissue interactions during fetal development and oncogenesis. However, the role of serum Tn-C in non-small cell lung cancer (NSCLC) has not been clarified.In this study, we determined the serum levels of Tn-C among NSCLC patients who underwent surgery, as well as other factors implicated for angiogenesis, to address the clinical implications in NSCLC.The median concentration of serum Tn-C in NSCLC patients was slightly higher than that of normal controls, but this difference was not statistically significant. There was a positive correlation between serum Tn-C levels and microvessel density (MVD), serum osteopontin (OPN) and vascular endothelial growth factor (VEGF). In contrast, there was no correlation between serum Tn-C levels and serum carcinoembryonic antigen (CEA) and sialyl lewis-X (SLX) levels. The overall survival of patients with low Tn-C levels (96 ng/ml) was significantly greater than that of patients with high Tn-C levels (or =96 ng/ml). Intratumoral Tn-C expression was co-localized with expression of microvessels in the stroma of the cancer cells by immunohistochemical analysis. Moreover, enhanced in vitro migration of human umbilical vascular endothelial cells (HUVEC) was induced by recombinant Tn-C. Collectively, Tn-C may play an important role in angiogenesis of patients with NSCLC, and the determination of serum Tn-C may be useful in predicting intratumoral vasculature and patients' prognosis. |
| Databáze: | OpenAIRE |
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