[The inhibition by the tumor necrosis factor of the death and DNA fragmentation of lymphoid cells in irradiated rats]

Autor:	S Ia, Proskuriakov, B P, Ivannik, S E, Aleksandrova, R V, Sin'kova, E A, Degtiareva, N I, Riabchenko
Rok vydání:	1992
Předmět:	Male Time Factors Cell Death Tumor Necrosis Factor-alpha DNA Single-Stranded Thymus Gland Recombinant Proteins Rats Polydeoxyribonucleotides Bone Marrow Gamma Rays Depression Chemical Animals Humans Lymphocytes DNA Damage
Zdroj:	Radiobiologiia. 32(4)
ISSN:	0033-8192
Popis:	The influence of a tumor necrosis factor, administered 16 h before irradiation of rats, on the radiation response of thymus and bone marrow cells has been investigated. Three and 6 h after irradiation the following indices were analyzed: the number of apoptotic cells in the thymus; the accumulation of polydeoxyribonucleotides and the appearance of single-strand breaks in DNA of bone marrow and thymus cells; and the electrophoretic properties of thymocyte DNA. The injection of a tumor necrosis factor reduced the number of polydeoxyribonucleotides, inhibited internucleosome DNA fragmentation, and did not influence the formation of single-strand breaks in DNA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a67bcee8311b0bd0a395bf9391bac46d https://pubmed.ncbi.nlm.nih.gov/1410288 Zobrazit plný text záznamu