| Autor: |
Weber, Matthew A., de Choisy, Gemma, Thangavel, Ramasamy, Conlon, Mackenzie M., Abdelmotilib, Hisham A., Halhouli, Oday, Zhang, Qiang, Geerling, Joel C., Narayanan, Nandakumar S., Aldridge, Georgina M. |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
bioRxiv |
| Popis: |
Parkinson ‘s disease dementia (PDD) and Lewy Body dementia (LBD) are characterized by diffuse spread of alpha-synuclein (α-syn) throughout the brain. These patients have a neuropsychological pattern of deficits that include executive dysfunction, including abnormalities in planning, timing, working memory, and behavioral flexibility. The prefrontal cortex (PFC) plays a major role in normal executive function and often develops α-syn aggregates in LBD and PDD. To investigate the consequences of α-syn pathology in the cortex, we injected human α-syn pre-formed fibrils into the PFC of wildtype mice. We report that PFC PFFs: 1) induced α-syn deposition in multiple cortical and subcortical regions with sparse aggregation in midbrain and brainstem nuclei; 2) did not affect interval timing or working memory but did mildly alter behavioral flexibility as measured by reversal learning; 3) increased open field exploration; and 4) did not affect susceptibility to model of cortical-dominant pathology adds to our understanding of the etiology of varied symptoms in PDD and LBD. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
