| Autor: |
K S, Coyne, V, Elinoff, D A, Gordon, D Y, Deng, M, Brodsky, D B, Glasser, Z, Jumadilova, M, Carlsson |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
International journal of clinical practice. 62(6) |
| ISSN: |
1742-1241 |
| Popis: |
Relationships were evaluated between treatment-related improvements in overactive bladder (OAB) symptoms as recorded in bladder diaries and patient-reported symptom bother, bladder-related problems and health-related quality of life (HRQL).A post hoc analysis was performed on data from patients with OAB (n = 863) enrolled in a 12-week open-label trial of tolterodine extended release (ER) in a primary care setting. At baseline and week 12, patients recorded every micturition, urgency episode and urgency urinary incontinence episode in 3-day bladder diaries. Patients also completed the Overactive Bladder Questionnaire (OAB-q) and Patient Perception of Bladder Condition (PPBC). Relationships between week 12 changes in bladder diary variables and OAB-q and PPBC scores were evaluated using Spearman correlations.By week 12, tolterodine ER-related improvements in all bladder diary variables were significantly correlated with improvements on the PPBC (r = 0.26-0.36; p0.001), OAB-q Symptom Bother scale (r = 0.30-0.51; p0.001), and all OAB-q HRQL domains (r = -0.24 to -0.42; p0.001), although the correlations were generally small to moderate in size. Improvements on the PPBC were also significantly correlated with improvements on the OAB-q Symptom Bother scale (r = 0.63; p0.001) and all HRQL domains (r = -0.40 to -0.59; p0.001).Tolterodine ER-related improvements in OAB symptoms (assessed by diary variables) and patients' perceptions of the changes in symptom bother, bladder-related problems and HRQL (assessed by PPBC and OAB-q) were significantly correlated. The OAB-q and the PPBC provide a relevant and important patient perspective for OAB treatment evaluation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
