DNA methylation in the medial prefrontal cortex regulates alcohol-related behavior in rats

Autor:	Heng Zhen, Cui, Mi Zhu, Sun, Run Zhi, Wang, Chen Yu, Li, Yu Xuan, Huang, Qiu Ju, Huang, Xiao Meng, Qiao
Rok vydání:	2020
Předmět:	Male Rats Sprague-Dawley Alcoholism Behavior Animal Methyl-CpG-Binding Protein 2 Animals Prefrontal Cortex DNA (Cytosine-5-)-Methyltransferases DNA Methylation Promoter Regions Genetic Locomotion Rats
Zdroj:	Yi chuan = Hereditas. 42(1)
ISSN:	0253-9772
Popis:	Alcohol abuse causes tissue and organ damage, and may participate neuropsychiatric diseases. Studies have shown that DNA methylation plays an important role in gene expression and behavioral changes induced by alcohol, however the causative neurobiological mechanisms have not been clarified. In this study, 32 healthy adult male SD rats were randomly divided into a drinking water control group (酒精滥用不仅导致组织器官损伤,还易诱发神经精神疾病。研究表明,DNA甲基化在酒精诱导基因表达和行为改变中发挥重要作用,但具体的神经生物学机制尚未被阐明。为了探索DNA甲基化在酒精滥用中的作用机制,本研究选取健康成年雄性 SD大鼠(
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a6686d24cc7159e172aa466845900ff2 https://pubmed.ncbi.nlm.nih.gov/31956101 Zobrazit plný text záznamu