GFP-fused yeast cells as whole-cell biosensors for genotoxicity evaluation of nitrosamines

Autor:	Ying, He, Haotian, Ding, Xingya, Xia, Wenyi, Qi, Huaisong, Wang, Wenyuan, Liu, Feng, Zheng
Rok vydání:	2021
Předmět:	Nitrosamines Animals Biosensing Techniques Saccharomyces cerevisiae DNA Damage Mutagens
Zdroj:	Applied microbiology and biotechnology. 105(13)
ISSN:	1432-0614
Popis:	Nitrosamine compounds, represented by N-nitrosodimethylamine, are regarded as potentially genotoxic impurities (PGIs) due to their hazard warning structure, which has attracted great attention of pharmaceutical companies and regulatory authorities. At present, great research gaps exist in genotoxicity assessment and carcinogenicity comparison of nitrosamine compounds. In this work, a collection of GFP-fused yeast cells representing DNA damage repair pathways were used to evaluate the genotoxicity of eight nitrosamine compounds (10
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a6430b02e60272d70da0380bc1fa1ffa https://pubmed.ncbi.nlm.nih.gov/34228183 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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