| Autor: |
R, McGinnis, F, Child, S, Clayton, S, Davies, W, Lenney, T, Illig, M, Wjst, N, Spurr, C, Debouck, A H, Hajeer, W E R, Ollier, R, Strange, A A, Fryer |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics. 29(6) |
| ISSN: |
0960-7420 |
| Popis: |
English and German nuclear families containing multiple asthmatic children and asthmatic parents were analysed to retest a recently reported association between resistance to asthma and the delta32 allele of chemokine receptor 5 (CCR5). Analysis of the families by the transmission-disequilibrium test (TDT) revealed a non-significant trend in the English families that provided marginal confirmation of the association (P0.125), but no similar trend was observed in the German families. Case-control comparison of delta32 allele and genotype frequencies in asthmatic vs. non-asthmatic parents revealed a significantly lower frequency of delta32 in asthmatic English parents (P0.009) and a similar but non-significant trend in German parents (P0.265). Taken together, the pattern of results provides confirmation for the previously observed delta32-asthma association and indicates that susceptibility to asthma may be influenced by CCR5 or another gene in chromosomal region 3p21. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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