| Autor: |
K, van Besien, H, Demuynck, C F, Lemaistre, M A, Bogaerts, R, Champlin |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Bone marrow transplantation. 15(2) |
| ISSN: |
0268-3369 |
| Popis: |
Conditioning regimens for allogeneic bone marrow transplantation are designed to eradicate malignant cells and to provide sufficient immunosuppression for engraftment of donor marrow. Total body irradiation and high-dose cyclophosphamide are the most established immunosuppressive agents used for this purpose. It is uncertain whether other alkylating agent-based conditioning regimens are sufficiently immunosuppressive to allow engraftment of allogeneic marrow. We report four patients who had prompt engraftment after conditioning with melphalan-based chemotherapy regimens (BEAM or busulfan/melphalan). Two patients survived without disease for a prolonged period, indicating that these melphalan regimens are sufficiently immunosuppressive to allow sustained engraftment and donor hematopoiesis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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