| Autor: |
P M, Lam, L P, Cheung, C M Y, Choy, Y P, Lau, C, Haines |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 16(2) |
| ISSN: |
0951-3590 |
| Popis: |
Gonadotropin releasing hormone agonists (GnRHa) are commonly used during in vitro fertilization and embryo transfer (IVF/ET) treatment cycles to downregulate the hypothalamic-pituitary-ovarian axis prior to ovarian stimulation with gonadotropins. It has been suggested that profound downregulation may have an adverse effect on IVF/ET outcome. The aim of this study was to examine the relationship between the degree of downregulation and IVF/ET outcome. A retrospective analysis was performed on 151 IVF/ET cycles conducted over a six month period. Intensity of downregulation was assessed using measurements of serum concentrations of luteinizing hormone (LH) and estradiol (E2) made at the end of a two week downregulation period. There was no correlation between serum concentration of LH (whether used alone or in combination with E2) and IVF/ET pregnancy rates. However, those subjects who were more suppressed according to the E2 concentration (148 pmol/l, [median]) required significantly more gonadotropins (3306 IU versus 2863 IU, p0.05) and took longer for follicles to reach maturity (10.9 days versus 9.7 days, p0.05). They also had a lower pregnancy rate per embryo transfer (10.4% versus 28.6%, p0.05) compared with those having a higher basal E2 concentration. We conclude from this study that the basal serum E2 concentration rather than the LH concentration is a more sensitive indicator of the intensity of downregulation by GnRHa and it may be a better predictor of IVF outcome. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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