| Popis: |
To investigate the mechanism of protective effect of estrogen on cerebral damage in ischemic stroke by measuring the estrogen(2) (E(2)), blood lipid, interleukin-1 beta (IL-1 beta), nitric oxide (NO), and also assessment according to national institute of health stroke scale (NIHSS) score, in order to improve the treatment of cerebral infarction.Forty male patients, in whom cerebral infarction due to thrombosis of middle cerebral artery was confirmed by CT or magnetic resonance imaging (MRI), were divided into two groups: E(2) therapy (20 cases) and routine therapy (20 cases). Routine therapy was the same in both groups, except 2 mg of E(2) was orally given (2 times a day) to the E(2) therapy group. E(2), testosterone (Ts), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), IL-1 beta, NO, and NIHSS score were measured in each patient at time points of 0, 3, 7, 14 and 21 days.In E(2) group, HDL-C and E(2) were increased significantly, and TC and LDL-C were decreased significantly from 3 days on after treatment, and the changes were obviously more marked than that of routine therapy group (all P0.05). The changes in TG and Ts were not obvious. NO, IL-1 beta were increased significantly (both P0.05), and NIHSS score was decreased in routine group form 14 days on after treatment. NO and IL-beta in E(2) group were lower than those in routine therapy group from 3 days on, and the NIHSS score was significantly lower on 14 days and 21 days in E(2) group (both P0.05).The protective effect of E(2) is obvious. It may be due to the results of modulation of blood fat, anti-inflammation and modulation of NO production by the action of E(2). Low dose and short time therapy of E(2) may be beneficial to the patient. |
