| Autor: |
Benjamin, Valdez-Salas, Sandra, Castillo-Uribe, Ernesto, Beltran-Partida, Mario, Curiel-Alvarez, Oscar, Perez-Landeros, Minerva, Guerra-Balcazar, Nelson, Cheng, Daniel, Gonzalez-Mendoza, Olivia, Flores-Peñaloza |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
International journal of nanomedicine. 17 |
| ISSN: |
1178-2013 |
| Popis: |
Titanium (Ti) and its alloys (eg, TiWe evaluated the bone-forming functional properties of osteoblasts on synthesized TiOThe diabetic conditions depressed the initial osteoblast growth ability, as evidenced by altered early cell adhesion and reduced proliferation. Nonetheless, after three days, the diabetic damage was suppressed by the NTs, enhancing the osteoblast activity. Therefore, the osteogenic markers of bone formation and the differentiation of osteoblasts were reactivated by the nanoconfigured surfaces. Far more importantly, collagen secretion and bone-matrix mineralization were stimulated and conducted to levels similar to those of the control of FBS conditions, in comparison to the control alloy, which was not able to reach similar levels of bone functionality than the NTs.Our study brings knowledge for the potential application of nanostructured biomaterials to work as an integrative platform under the detrimental metabolic status present in diabetic conditions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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