| Autor: |
S R, Weiler, S, Mou, C S, DeBerry, J R, Keller, F W, Ruscetti, D K, Ferris, D L, Longo, D, Linnekin |
| Rok vydání: |
1996 |
| Předmět: |
|
| Zdroj: |
Blood. 87(9) |
| ISSN: |
0006-4971 |
| Popis: |
Stem cell factor (SCF) is a hematopoietic growth factor that interacts with the receptor tyrosine kinase, c-kit. We have found that SCF-stimulates rapid and transient tyrosine phosphorylation of JAK2 in human and murine cell lines, as well as in normal human progenitor cells. JAK2 and c-kit were associated in unstimulated cells with further recruitment of JAK2 to the c-kit receptor complex after SCF stimulation. Treatment of cells with JAK2 antisense oligonucleotides resulted in a 46% decrease in SCF-induced proliferation. These data demonstrate that SCF induces tyrosine phosphorylation of JAK2 and suggest that JAK2 is a component of the SCF signal transduction pathway. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
