Bronchodilator Effect of Tiotropium via RespimatⓇ Administered with a Spacer in Patients with Chronic Obstructive Pulmonary Disease (COPD)
| Autor: | Ogasawara, Takashi, Sakata, Jun, Aoshima, Yoichiro, Tanaka, Kazuki, Yano, Toshiaki, Kasamatsu, Norio |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Cross-Over Studies Nebulizers and Vaporizers Middle Aged RespimatⓇ respiratory tract diseases chronic obstructive pulmonary disease Bronchodilator Agents Respiratory Function Tests Pulmonary Disease Chronic Obstructive tiotropium Forced Expiratory Volume Administration Inhalation Terbutaline Humans Original Article spacer Female Prospective Studies Tiotropium Bromide Aged |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | Objective Among elderly patients with chronic obstructive pulmonary disease (COPD), there are some patients who cannot inhale tiotropium via RespimatⓇ due to poor hand-lung coordination. This study aimed to examine whether or not tiotropium inhalation therapy using RespimatⓇ with a spacer increased the forced expiratory volume in 1 s (FEV1) in patients with COPD. Methods A randomized, crossover, single-center study was conducted in 18 patients with stable COPD. Tiotropium (5 μg) via RespimatⓇ with or without a spacer (AeroChamberⓇ) was administered for 2 weeks. Following a 2-week washout period using a transdermal tulobuterol patch (2 mg per day), participants were then crossed over to the other inhalation therapy with respect to spacer use. The trough FEV1 was measured at every visit using a spirometer. A questionnaire regarding inhalation therapy was administered to patients at the final visit. Results The administration of tiotropium via RespimatⓇ both with and without a spacer significantly increased the trough FEV1 from baseline during each treatment period, with mean differences of 115.0±169.6 mL and 92.8±128.1 mL, respectively. There was no significant difference in the change in the trough FEV1 between the 2 procedures (p=0.66). A total of 86% of patients reported that inhalation using a spacer was not difficult, and more than half also rated both the usage and maintenance of the AeroChamberⓇ as easy. Conclusion Tiotropium inhalation therapy administered via RespimatⓇ using a spacer exerted a bronchodilatory effect similar to that observed with tiotropium RespimatⓇ alone. |
| Databáze: | OpenAIRE |
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