| Autor: |
S, Takeda, P, Sim, D, Horrobin, K, Chisholm, V, Simmons, G, Ells, D, Jenkins, N, Morsefisher |
| Rok vydání: |
2011 |
| Zdroj: |
International journal of oncology. 1(7) |
| ISSN: |
1019-6439 |
| Popis: |
Intracellular free fatty acid (FFA) release and peroxidation of polyunsaturated fatty acid (PUFA) were studied in cultured human breast cancer cells (ZR-75-1) exposed to gamma-linolenic acid with iron (GLA + Fe). This treatment results in cell death. Increased intracellular FFA were observed in association with both the accelerated peroxidation of PUFA and the killing effect. Vitamin E reduced all three effects. The FFA were methyl esterified and analyzed by gas chromatography-mass spectrometry. The identified FFAs were 16: 0, 18: 3, 20: 3 and 20: 4 (numbers of carbons and double bonds indicated). These results suggest an association of intracellular FFA release with the peroxidation of PUFA and the cancer cell-killing by GLA in the presence of iron. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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