A Stutter in the Coiled-Coil Domain of
| Autor: | Tulsi, Upadhyay, Upasana S, Potteth, Vaibhav V, Karekar, Ishu, Saraogi |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Biochemistry. 60(17) |
| ISSN: | 1520-4995 |
| Popis: | In bacteria, the co-chaperone GrpE acts as a nucleotide exchange factor and plays an important role in controlling the chaperone cycle of DnaK. The functional form of GrpE is an asymmetric dimer, consisting of a non-ideal coiled coil. Partial unfolding of this region during heat stress results in reduced nucleotide exchange and disrupts protein folding by DnaK. In this study, we elucidate the role of non-ideality in the coiled-coil domain of |
| Databáze: | OpenAIRE |
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