| Autor: |
Shuai-Bo, Han, Jing-Ying, Wei, Xiao-Chong, Peng, Rong, Liu, Shan-Shan, Gong, Qi, Sun |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Molecules |
| ISSN: |
1420-3049 |
| Popis: |
Hf(OTf)4 was identified as a highly potent catalyst (0.1–0.5 mol%) for three-component Mannich reaction under solvent-free conditions. Hf(OTf)4-catalyzed Mannich reaction exhibited excellent regioselectivity and diastereoselectivity when alkyl ketones were employed as substrates. 1H NMR tracing of the H/D exchange reaction of ketones in MeOH-d4 indicated that Hf(OTf)4 could significantly promote the keto-enol tautomerization, thereby contributing to the acceleration of reaction rate. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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