Analgesic and antiinflammatory activity screening of 6-acyl-3-piperidinomethyl-2(3H)-benzoxazolone derivatives

Autor:	D D, Erol, R, Demirdamar
Rok vydání:	1994
Předmět:	Analgesics Benzoxazoles Mice Anti-Inflammatory Agents Non-Steroidal Animals Female
Zdroj:	Farmaco (Societa chimica italiana : 1989). 49(10)
ISSN:	0014-827X
Popis:	6-Acetyl-2(3H)-benzoxazolone derivatives were reacted with appropriate piperidine derivatives and formaldehyde in methanol to give the corresponding 6-acyl-3-piperidinomethyl-2(3H)-benzoxazolones. The obtained compounds were screened for their analgesic and antiinflammatory activities. Analgesic activity of these compounds was investigated by modified Koster test. Antiinflammatory activity was assayed by using carrageenan induced mouse paw edema test and arachidonic acid edema. The 15 compounds synthesized showed good analgesic activities; compounds 1,3 and 6 moved to be active inhibitors of edema.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a55cdce8a87732f20c083af666ea1987 https://pubmed.ncbi.nlm.nih.gov/7826474 Zobrazit plný text záznamu