| Autor: |
Suresh, Sadhasivam, Mau, Sinha, Swamini, Saini, Simar Preet, Kaur, Tanvi, Gupta, Shiladitya, Sengupta, Shamik, Ghosh, Kabir, Sardana |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Dermatologic therapy. 29(6) |
| ISSN: |
1529-8019 |
| Popis: |
Acne vulgaris is a multifactorial skin disease associated with the colonization of Propionibacterium acnes. Antibiotics are a mainstay of treatment for acne, yet the emergence of resistance against the currently approved antibiotics is a serious concern. In this case report, a slow responder had multiple Propionibacterium acnes isolates with varied levels of sensitivity to the conventional antibiotics. The bacterial isolates obtained from acne samples collected from the patient were analyzed for phylogeny, and was found to be largely restricted to two different lineage patterns. Propionibacterium acnes phylotype IA1, which is considered to be pathogenic, displayed clindamycin sensitivity, but phylotype IB, which is associated with commensals, exhibited high clindamycin resistance. Sensitivity analysis revealed uniform resistance to macrolides, but susceptibility to tetracycline and nadifloxacin. These results implicate Propionibacterium acnes in the pathophysiology of acne vulgaris, although the lines between commensal and pathological phylotypes may be blurred. Switching the patient to a combination of minocycline and nadifloxacin resulted in a significant improvement in the clinical lesions. Such a science-driven judicious selection of antibiotics can minimize the probability of development of resistance, and might be the way forward in the treatment of acne. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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