[The evaluation of the reactogenicity and immunological activity of an inactivated 3-component influenza vaccine with an elevated hemagglutinin concentration in the inoculation dosage]

Autor:	I G, Marinich, A S, Shadrin, A N, Naĭkhin, Iu G, Ivannikov, N P, Kuznetsov, V I, Karogodina, A M, Shcherbinskaia, E G, Voronina, L D, Stepankovskaia, I V, Eliseeva
Rok vydání:	1991
Předmět:	Adult Influenza B virus Time Factors Urban Population Vaccines Inactivated Influenza A virus Influenza Vaccines Dose-Response Relationship Immunologic Drug Evaluation Hemagglutinins Viral Humans Antibodies Viral USSR
Zdroj:	Zhurnal mikrobiologii, epidemiologii i immunobiologii. (7)
ISSN:	0372-9311
Popis:	In this work the reactogenic properties and antigenic potency of inactivated trivalent influenza vaccine, obtained by elution and centrifugation and containing up to 9-11 micrograms of hemagglutinin for influenza viruses A(H1N1) and A(H3N2) and up to 14 micrograms for influenza virus B, were studied. The reactogenicity of the preparation was found to correspond to the regulations. The immunogenic potency characteristics of individual batches of this trivaccine were higher than the immunogenicity of divaccines, but did not meet the requirements of technical specifications.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a542d4ebc64d74fb573b6694101af8e8 https://pubmed.ncbi.nlm.nih.gov/1950267 Zobrazit plný text záznamu