| Autor: |
N V, Belosludtseva, T A, Kireeva, K N, Belosludtsev, N V, Khunderyakova, G D, Mironova |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Bulletin of experimental biology and medicine. 171(6) |
| ISSN: |
1573-8221 |
| Popis: |
The parameters of coupled respiration and transport of calcium ions in mitochondria isolated from the heart of rats were studied in two modes of exposure to epinephrine for modelling myocardial damage. In 24 h after injection of 1.5 mg/kg epinephrine to rats, we observed a decrease in the efficiency of oxidative phosphorylation in heart mitochondria in the presence of both NADH- and FADH-dependent respiratory substrates. Increasing the epinephrine dose and exposure (2 mg/kg, 72 h) led to a more pronounced decrease in the ADP/O coefficient when succinate was used as a substrate, which indicated a predominant decrease in the activity of complex II of the respiratory chain. The injection of epinephrine in the two modes resulted in a decrease in the rate of calcium entry in rat heart mitochondria, but had no effect on mitochondrial calcium retention capacity, which reflects the resistance of the organelles to the induction of the Са |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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