Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice

Autor: Taija, Heinosalo, Kalle T, Rytkönen, Niina, Saarinen, Päivi, Järvensivu, Pauliina, Damdimopoulou, Leena, Strauss, Satu, Orasniemi, Petricia, Horshauge, Michael, Gabriel, Pasi, Koskimies, Claes, Ohlsson, Pauliina, Kronqvist, Matti, Poutanen
Rok vydání: 2022
Předmět:
Zdroj: International journal of molecular sciences. 23(9)
ISSN: 1422-0067
Popis: Hydroxysteroid (17beta) dehydrogenase type 1 (HSD17B1) is an enzyme that converts estrone to estradiol, while adenomyosis is an estrogen-dependent disease with poorly understood pathophysiology. In the present study, we show that mice universally over-expressing human estrogen biosynthetic enzyme
Databáze: OpenAIRE
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