| Autor: |
H, Gołebiewski, A, Romaniuk |
| Rok vydání: |
1985 |
| Předmět: |
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| Zdroj: |
Acta neurobiologiae experimentalis. 45(1-2) |
| ISSN: |
0065-1400 |
| Popis: |
The influence of bilateral injections of serotonin (5-HT) and methysergide (MET) to antero-medial hypothalamus (HA) on carbachol-induced emotional-defensive behavior was investigated. Earlier (15 min) stimulation of 5-HT receptors in HA region by 5-HT injections evoked a decrease in the level of vocal response (number and time of growling), while previous blocking of these receptors by means of MET brought about a considerable increase of vocalization level evoked by carbachol (Cch) injections (10 pg) to the same loci of HA. Intrahypothalamic injections of 5-HT alone or MET did not evoke any observable changes in the animals behavior. The alterations of the level of Cch-induced vocal response 3 to 35 days after chemical damage of 5-HT neurons in HA or in the middle forebrain bundle (MFB) in posterolateral hypothalamus caused by 5,7-dihydroxytryptamine were examined. Local neurotoxin injections both to MFB and to HA evoked a long lasting increase in the level of Cch-induced vocalization, which began on the 5th-7th day after lesioning and lasted till the completion of the experiment (35 days). Results data indicate that the 5-HT system exerts an inhibiting influence on the emotional-defensive behavior induced by the cholinergic system. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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