| Autor: |
Huixian, Xu, Jing, Xie, Yanna, Lei, Qingsong, Cui, Minggen, Jin |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Zhonghua wei zhong bing ji jiu yi xue. 30(8) |
| ISSN: |
2095-4352 |
| Popis: |
To investigate the anti-inflammatory effect of penehyclidine hydrochloride on oleic acid-induced acute respiratory distress syndrome (ARDS) in rats.According to randomize number table method, 30 adult male Sprague-Dawley (SD) rats were divided into control group, model group and treatment group. Catheters were placed in femoral vein in each group. The control group was injected with 1.1 mL/kg physiological saline; the model group was injected with 0.1 mL/kg oleic acid and then injected with 1.0 mL/kg normal saline to establish ARDS model; the treatment group was injected with 0.1 mL/kg oleic acid and then injected with 1.0 mL/kg penehyclidine hydrochloride. At 3 hours after the model was established, blood gas analysis was carried out in each group, oxygenation index (PaOCompared with the control group, PaOPenehyclidine hydrochloride can effectively improve the oxygenation, alleviate lung injury and reduce pulmonary edema in oleic acid induced ARDS rat by decreasing lung W/D ratio, inhibiting oxidative stress and inflammatory response. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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