[Evaluation of reactogenicity and immunogenicity of Bubo-M, the Russian combined vaccine for immunization of adults against diphtheria, tetanus and viral hepatitis B]

Autor: I V, Fel'dblium, N N, Vorob'eva, A M, Nikolaeva, V N, Borisova, V A, Mel'nikov, M V, Budanov, I A, Iakovleva, A V, Kaz'ianin, E V, Pushkareva, D V, Griaznova, N V, Shalunova, O V, Perelygina, N A, Ozeretskovskiĭ, T A, Bektimirov, N V, Isaeva
Rok vydání: 2002
Předmět:
Zdroj: Zhurnal mikrobiologii, epidemiologii i immunobiologii. (5)
ISSN: 0372-9311
Popis: Bubo-M, the first Russian associated vaccine, was found to have low reactogenicity and high immunogenic potency. The frequency of postvaccinal reactions in the group of persons immunized with Bubo-M (20%) appeared to be considerably lower than among persons who received the combined injection of adsorbed DT toxoid with reduced antigen content and vaccine against hepatitis B (47.7%). Following the course of vaccination the level of anti-HBs considerably exceeded the protective level. Immune response to the diphtheria and tetanus components of Bubo-M exceeded that observed after immunization with absorbed DT toxoid with reduced antigen content (p0.05).
Databáze: OpenAIRE