| Autor: |
Germaine, Savoiu, Simona, Drăgan, Carmen, Cristescu, Corina, Serban, Lavinia, Noveanus, Daniela, Ionescu, T, Nicola, Oana, Duicu, Andreea, Raducan, Mirela, Voicu |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi. 113(2) |
| ISSN: |
0048-7848 |
| Popis: |
Oxidation of LDL plays an important role in the pathogenesis of atherosclerosis. Increased wall thickness precedes plaque formation and noninvasive B-mode ultrasonographic measurement of IMT is considered a useful marker of the development of the carotid atherosclerosis.The present study was designed to assess the association of oxidized low-density lipoprotein (ox-LDL) with carotid intima-media thickness (IMT) in hypertensive patients. Oxidized LDL (enzyme-linked immunosorbent assay, Elisa) and carotid IMT (high-resolution B-mode ultrasonography) were assessed in 74 patients, aged between 45 and 65 years, diagnosticated with arterial hypertension.We observed significantly higher plasma levels of total cholesterol (236.32 +/- 41.96 mg/dl), LDL cholesterol (166.92 +/- 38.55 mg/dl), triglycerides (180.79 +/- 72.05 mg/dl) and low plasma levels of HDL-cholesterol (33.24 +/- 7.99 mg/dl) in all patients. We noticed higher plasma levels of ox-LDL (77.34 +/- 24.78 mg/dl) and carotid IMT was increased (1.41 +/- 0.31 mm). The statistically analysis done using Pearson's test and Student's t - test indicated that there were correlations of ox-LDL with: IMT (p0.05, r = 0.408), total cholesterol (p0.05, r = 0.498), LDL-cholesterol (p0.05, r = 0.527), triglycerides (p0.05, r = 0.385) and HDL-cholesterol (p0.05, r = -0.442).Higher plasma levels of ox-LDL were associated with increased carotid IMT in hypertensive patients. Measurement of plasma Ox-LDL and carotid IMT may represent useful markers for atherosclerosis and may represent potential targets for therapeutic interventions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
