| Autor: |
Z, Yao, K, Hartung, H G, Deicher, G, Brünnler, M P, Bettinotti, E, Keller, C, Paul, C, Gawron, S, Mikschl, E, Albert |
| Rok vydání: |
1993 |
| Předmět: |
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| Zdroj: |
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics. 20(4) |
| ISSN: |
0960-7420 |
| Popis: |
Genomic DNA of 178 German Caucasian patients with systemic lupus erythematosus are studied for HLA-DP locus by using PCR and DIG-ddUTP-labelled oligonucleotide probes. A significant increase of DPB1*0101 is observed in SLE patients compared with healthy controls (chi 2 = 15.27, p.c.0.004). DPB1*0501 and *0901 are also slightly increased (chi 2 = 5.85, P0.05, p.c. = NS; chi 2 = 5.64, P0.05, p.c. = NS). There is no significant difference in frequency of DP alleles between male and female patients. Since a linkage disequilibrium between HLA-B, DR and DP loci is found in our SLE patients, an analysis is performed assessing the relative importance of these HLA-markers to SLE. The results show that the increase of DPB1*0101 in SLE patients is associated with the HLA-B8, DR3 haplotype and it suggests a more important role for HLA-B8, DR3 or genes within this haplotype than for DPB1*0101 in the genetic predisposition for SLE. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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