Experimental evidence of a potentiation by alpha,beta magnesium L-aspartate of the anxiolytic effect of diazepam. Four-plate test in mice and qEEG study in primates

Autor:	M G, Borzeix, J P, Akimjak, J M, Dupont, R, Cahn, J, Cahn
Rok vydání:	1991
Předmět:	Male Aspartic Acid Macaca fascicularis Mice Psychological Tests Diazepam Animals Electroencephalography Mice Inbred Strains Anxiety
Zdroj:	Magnesium research. 4(3-4)
ISSN:	0953-1424
Popis:	The anxiolytic dose 50 (AD50) of diazepam was determined in mice in the four-plate test and the EEG pattern elicited by diazepam was quantified by Fast Fourier Transformation in monkeys. The AD50 of diazepam was reduced by 2.7-fold after repeated treatment with alpha,beta magnesium L-aspartate. The increased EEG fast activity elicited by diazepam at the expense of slow activities was reinforced and more long lasting after alpha,beta magnesium L-aspartate treatment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a4737483f5828b936329534ea12b0362 https://pubmed.ncbi.nlm.nih.gov/1799555 Zobrazit plný text záznamu