Prohibitin ligands: a growing armamentarium to tackle cancers, osteoporosis, inflammatory, cardiac and neurological diseases

Autor:	Dong, Wang, Redouane, Tabti, Sabria, Elderwish, Hussein, Abou-Hamdan, Amel, Djehal, Peng, Yu, Hajime, Yurugi, Krishnaraj, Rajalingam, Canan G, Nebigil, Laurent, Désaubry
Rok vydání:	2019
Předmět:	Repressor Proteins Heart Diseases Neoplasms Prohibitins Gene Expression Humans Osteoporosis Nervous System Diseases Ligands Protein Processing Post-Translational Signal Transduction
Zdroj:	Cellular and molecular life sciences : CMLSReferences. 77(18)
ISSN:	1420-9071
Popis:	Over the last three decades, the scaffold proteins prohibitins-1 and -2 (PHB1/2) have emerged as key signaling proteins regulating a myriad of signaling pathways in health and diseases. Small molecules targeting PHBs display promising effects against cancers, osteoporosis, inflammatory, cardiac and neurodegenerative diseases. This review provides an updated overview of the various classes of PHB ligands, with an emphasis on their mechanism of action and therapeutic potential. We also describe how these ligands have been used to explore PHB signaling in different physiological and pathological settings.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a4623711a656589cf3d7291ac2cd2f18 https://pubmed.ncbi.nlm.nih.gov/32062751 Zobrazit plný text záznamu Full text from SpringerLink