Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolution

Autor:	A K, Todd, A, Adams, J H, Thorpe, W A, Denny, L P, Wakelin, C J, Cardin
Rok vydání:	1999
Předmět:	Models Molecular DNA Topoisomerases Type II DNA Topoisomerases Type I Acridines Nucleic Acid Conformation Topoisomerase II Inhibitors Antineoplastic Agents Hydrogen Bonding Topoisomerase I Inhibitors Crystallography X-Ray Intercalating Agents
Zdroj:	Journal of medicinal chemistry. 42(4)
ISSN:	0022-2623
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a460a984e0e49c12d2b1895e2bfaf063 https://pubmed.ncbi.nlm.nih.gov/10052960 Zobrazit plný text záznamu