The non-structural leader protein gene of foot-and-mouth disease virus is highly variable between serotypes

Autor:	M, George, R, Venkataramanan, C B, Gurumurthy, D, Hemadri
Rok vydání:	2001
Předmět:	Base Sequence Sequence Homology Amino Acid Foot-and-Mouth Disease Virus Sequence Homology Nucleic Acid DNA Viral Molecular Sequence Data Amino Acid Sequence Viral Nonstructural Proteins
Zdroj:	Virus genes. 22(3)
ISSN:	0920-8569
Popis:	Aphthoviruses are unique among picornaviruses in that they alone encode a functional L proteinase as the first component of the viral polyprotein. The L genes of a few Indian foot-and-mouth disease viruses were sequenced and compared with those available to study the extent of variation in this gene. Besides the two in-frame start codons present in all FMDV L genes, the Asia-I vaccine virus had an additional in-frame AUG (start) codon, at codon position 3. Amino acid sequence comparison revealed that 39.8% of positions were capable of accepting replacements, yet the residues of the catalytic dyad were totally conserved. Sequence comparison at the C-terminus of the protein indicated that K/R decreasing GAGQS is sufficient for L/P1 cleavage. Phylogenetic analysis based on the L gene sequences did not reveal any serotype-specific clustering. The probable implications of the observed high variability in this non-structural gene is briefly discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a450ee3fb23c9e7ddd5a5af51d5fb80b https://pubmed.ncbi.nlm.nih.gov/11450945 Zobrazit plný text záznamu Full text from SpringerLink