Protein Complex Production from the Drug Discovery Standpoint
| Autor: | Ismail, Moarefi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Transcription
Genetic Protein Engineering Recombinant Proteins Epigenesis Genetic Protein Subunits Structure-Activity Relationship Gene Expression Regulation Multiprotein Complexes Drug Discovery Animals Humans Biological Assay Molecular Targeted Therapy Enzyme Inhibitors Protein Multimerization Protein Structure Quaternary Signal Transduction |
| Zdroj: | Advances in experimental medicine and biology. 896 |
| ISSN: | 0065-2598 |
| Popis: | Small molecule drug discovery critically depends on the availability of meaningful in vitro assays to guide medicinal chemistry programs that are aimed at optimizing drug potency and selectivity. As it becomes increasingly evident, most disease relevant drug targets do not act as a single protein. In the body, they are instead generally found in complex with protein cofactors that are highly relevant for their correct function and regulation. This review highlights selected examples of the increasing trend to use biologically relevant protein complexes for rational drug discovery to reduce costly late phase attritions due to lack of efficacy or toxicity. |
| Databáze: | OpenAIRE |
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