Screening approach for chiral separation of pharmaceuticals part II. Reversed-phase liquid chromatography

Autor:	C, Perrin, N, Matthijs, D, Mangelings, C, Granier-Loyaux, M, Maftouh, D L, Massart, Y Vander, Heyden
Rok vydání:	2002
Předmět:	Pharmaceutical Preparations Solvents Stereoisomerism Buffers Hydrogen-Ion Concentration Acids Chromatography Liquid
Zdroj:	Journal of chromatography. A. 966(1-2)
ISSN:	0021-9673
Popis:	A screening strategy for the rapid separation of drug enantiomers by reversed-phase liquid chromatography was developed using three cellulose/amylose stationary phases. The key point to achieve enantioselectivity is the control of the compound ionisation. Only two mobile phases, i.e. an acidic phosphate buffer (pH 2.0) containing a chaotropic salt (KPF6) and a borate buffer (pH 9.0) mixed with acetonitrile, are used in the proposed strategy. This strategy was successfully applied to a set of 37 diverse chiral pharmaceuticals. Satisfactory enantioselectivity was achieved for 89% of them.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::a412716ab53271f37edd2505c820adf8 https://pubmed.ncbi.nlm.nih.gov/12214686 Zobrazit plný text záznamu Full Text from ScienceDirect