Antioxidative characteristics and inhibition of alpha-melanocyte-stimulating hormone-stimulated melanogenesis of vanillin and vanillic acid from Origanum vulgare
| Autor: | Tzung-Han, Chou, Hsiou-Yu, Ding, Wei Jing, Hung, Chia-Hua, Liang |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Melanins Vanillic Acid Mice Inbred ICR Cell Survival Plant Extracts Melanoma Experimental Fibroblasts Thiobarbituric Acid Reactive Substances Antioxidants Cell Line Mice Liver alpha-MSH Benzaldehydes Cell Line Tumor Origanum Models Animal Animals Lipid Peroxidation Reactive Oxygen Species Cells Cultured |
| Zdroj: | Experimental dermatology. 19(8) |
| ISSN: | 1600-0625 |
| Popis: | The antioxidant activities of vanillin and vanillic acid isolated from Origanum vulgare are investigated. These compounds may serve as agents for antimelanogenesis. Vanillic acid is a stronger antioxidant than vanillin, in terms of free radical scavenging activity, reducing power and inhibition of lipid peroxidation. The inhibition of cellular reactive oxygen species (ROS) in H(2)O(2)-treated BNLCL2 cells by vanillic acid exceeds that of ascorbic acid (AA) or trolox. In B16F0 cells stimulated with alpha-melanocyte-stimulating hormone (alpha-MSH), vanillic acid reduced cellular tyrosinase activity, DOPA oxidase and melanin contents, as well as down-regulated expressions of melanocortin-1 receptor (MC1R), microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related proteins 2 (TRP-2) and TRP-1. Vanillin did not express inhibition of tyrosinase activity. These results supported that vanillic acid is a significantly stronger antioxidant than vanillin and exhibited stronger antimelanogenesis performance because of the structural presence of the carboxyl group. |
| Databáze: | OpenAIRE |
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